Cure of murine Trypanosoma brucei rhodesiense infections with an S-adenosylmethionine decarboxylase inhibitor.

The compound 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine (MDL73811), a potent inhibitor of S-adenosylmethionine decarboxylase, was effective in mice against six of eight clinical isolates of Trypanosoma brucei rhodesiense, the causative agent of East African sleeping sickness. In combi...

Descripció completa

Dades bibliogràfiques

Publicat a:	Antimicrob Agents Chemother
Autors principals:	Bacchi, C J, Nathan, H C, Yarlett, N, Goldberg, B, McCann, P P, Bitonti, A J, Sjoerdsma, A
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 1992
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC245537/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1482141/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.36.12.2736
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!