Combination chemotherapy of drug-resistant Trypanosoma brucei rhodesiense infections in mice using DL-alpha-difluoromethylornithine and standard trypanocides.

Combinations of DL-alpha-difluoromethylornithine (DFMO; eflornithine; Ornidyl) with either suramin or melarsen oxide were found to be effective against acute laboratory model infections with Trypanosoma brucei rhodesiense. We used clinical isolates known to be resistant to these drugs when used sing...

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Main Authors: Bacchi, C J, Nathan, H C, Yarlett, N, Goldberg, B, McCann, P P, Sjoerdsma, A, Saric, M, Clarkson, A B
Formato: Artigo
Idioma:Inglês
Publicado: 1994
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC284498/
https://ncbi.nlm.nih.gov/pubmed/8203855
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