Combination chemotherapy of drug-resistant Trypanosoma brucei rhodesiense infections in mice using DL-alpha-difluoromethylornithine and standard trypanocides.

Combinations of DL-alpha-difluoromethylornithine (DFMO; eflornithine; Ornidyl) with either suramin or melarsen oxide were found to be effective against acute laboratory model infections with Trypanosoma brucei rhodesiense. We used clinical isolates known to be resistant to these drugs when used sing...

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Bibliographic Details
Main Authors: Bacchi, C J, Nathan, H C, Yarlett, N, Goldberg, B, McCann, P P, Sjoerdsma, A, Saric, M, Clarkson, A B
Format: Artigo
Language:Inglês
Published: 1994
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC284498/
https://ncbi.nlm.nih.gov/pubmed/8203855
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