Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of Stage 2 Human African Trypanosomiasis

समान संसाधन

• SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis
  द्वारा: Jacobs, Robert T., और अन्य
  प्रकाशित: (2011)
• Application of a resazurin-based high-throughput screening assay for the identification and progression of new treatments for human African trypanosomiasis
  द्वारा: Bowling, Tana, और अन्य
  प्रकाशित: (2012)
• Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis
  द्वारा: Nare, Bakela, और अन्य
  प्रकाशित: (2010)
• 2,4-Diaminopyrimidines as Potent Inhibitors of Trypanosoma brucei and Identification of Molecular Targets by a Chemical Proteomics Approach
  द्वारा: Mercer, Luke, और अन्य
  प्रकाशित: (2011)
• Discovery of Novel Benzoxaborole-Based Potent Antitrypanosomal Agents
  द्वारा: Ding, Dazhong, और अन्य
  प्रकाशित: (2010)