Discovery of Novel Benzoxaborole-Based Potent Antitrypanosomal Agents

[Image: see text] We report the discovery of benzoxaborole antitrypanosomal agents and their structure−activity relationships on central linkage groups and different substitution patterns in the sulfur-linked series. The compounds showed in vitro growth inhibition IC(50) values as low as 0.02 μg/mL...

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Main Authors: Ding, Dazhong, Zhao, Yaxue, Meng, Qingqing, Xie, Dongsheng, Nare, Bakela, Chen, Daitao, Bacchi, Cyrus J., Yarlett, Nigel, Zhang, Yong-Kang, Hernandez, Vincent, Xia, Yi, Freund, Yvonne, Abdulla, Maha, Ang, Kean-Hooi, Ratnam, Joseline, McKerrow, James H., Jacobs, Robert T., Zhou, Huchen, Plattner, Jacob J.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2010
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007846/
https://ncbi.nlm.nih.gov/pubmed/24900190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100013s
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