Trypanocidal Activity of 8-Methyl-5′-{[(Z)-4-Aminobut-2-enyl]-(Methylamino)}Adenosine (Genz-644131), an Adenosylmethionine Decarboxylase Inhibitor

Genzyme 644131, 8-methyl-5′-{[(Z)-4-aminobut-2-enyl](methylamino)}adenosine, is an analog of the enzyme activated S-adenosylmethionine decarboxylase (AdoMetDC) inhibitor and the trypanocidal agent MDL-7381, 5-{[(Z)-4-aminobut-2-enyl](methylamino)}adenosine. The analog differs from the parent in havi...

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Autors principals: Bacchi, Cyrus J., Barker, Robert H., Rodriguez, Aixa, Hirth, Bradford, Rattendi, Donna, Yarlett, Nigel, Hendrick, Clifford L., Sybertz, Edmund
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2009
Matèries:
Susceptibility
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715600/
https://ncbi.nlm.nih.gov/pubmed/19451291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00076-09
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