Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity

A series of alkanediamide-linked bisbenzamidines was synthesized and tested in vitro against a drug-sensitive strain of Trypanosoma brucei brucei, a drug-resistant strain of Trypanosoma brucei rhodesiense and Pneumocystis carinii. Bisbenzamidines linked with longer alkanediamide chains were potent i...

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Main Authors: Huang, Tien L., Eynde, Jean Jacques Vanden, Mayence, Annie, Collins, Margaret S., Cushion, Melanie T., Rattendi, Donna, Londono, Indira, Mazumder, Lakshman, Bacchi, Cyrus J., Yarlett, Nigel
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753751/
https://ncbi.nlm.nih.gov/pubmed/19736009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.08.073
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