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In Vitro Selection and In Vivo Efficacy of Piperazine- and Alkanediamide-Linked Bisbenzamidines against Pneumocystis Pneumonia in Mice

Bisbenzamidines, such as pentamidine isethionate, are aromatic dicationic compounds that are active against Pneumocystis and other microbes but are oftentimes toxic to the host. To identify potential anti-Pneumocystis agents, we synthesized bisbenzamidine derivatives in which the parent compound pen...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Cushion, Melanie T., Walzer, Peter D., Ashbaugh, Alan, Rebholz, Sandra, Brubaker, Ronald, Vanden Eynde, Jean Jacques, Mayence, Annie, Huang, Tien L.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 2006
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489771/
https://ncbi.nlm.nih.gov/pubmed/16801410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00126-06
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