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In Vitro Selection and In Vivo Efficacy of Piperazine- and Alkanediamide-Linked Bisbenzamidines against Pneumocystis Pneumonia in Mice

Bisbenzamidines, such as pentamidine isethionate, are aromatic dicationic compounds that are active against Pneumocystis and other microbes but are oftentimes toxic to the host. To identify potential anti-Pneumocystis agents, we synthesized bisbenzamidine derivatives in which the parent compound pen...

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Hlavní autoři: Cushion, Melanie T., Walzer, Peter D., Ashbaugh, Alan, Rebholz, Sandra, Brubaker, Ronald, Vanden Eynde, Jean Jacques, Mayence, Annie, Huang, Tien L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489771/
https://ncbi.nlm.nih.gov/pubmed/16801410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00126-06
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