Development of highly active anti-Pneumocystis bisbenzamidines: insight into the influence of selected substituents on the in vitro activity

Here we describe the potency of 21 pentamidine analogues against the fungal pathogen, Pneumocystis carinii, in an ATP bioluminescent assay with toxicity profiles in 2 mammalian cell lines. Reduction of two 5-methyl-1,2,4-oxadiazole rings was applied to the synthesis of acid-labile bisamidines. Anti-...

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Vydáno v:Medchemcomm
Hlavní autoři: Maciejewska, D., Żabiński, J., Rezler, M., Kaźmierczak, P., Collins, M. S., Ficker, L., Cushion, M. T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2017
Témata:
Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6071923/
https://ncbi.nlm.nih.gov/pubmed/30108719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7md00445a
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