Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis

Por Nare, Bakela, Wring, Stephen, Bacchi, Cyrus, Beaudet, Beth, Bowling, Tana, Brun, Reto, Chen, Daitao, Ding, Charles, Freund, Yvonne, Gaukel, Eric, Hussain, Ali, Jarnagin, Kurt, Jenks, Matthew, Kaiser, Marcel, Mercer, Luke, Mejia, Elena, Noe, Andy, Orr, Matt, Parham, Robin, Plattner, Jacob, Randolph, Ryan, Rattendi, Donna, Rewerts, Cindy, Sligar, Jessica, Yarlett, Nigel, Don, Robert, Jacobs, Robert
Publicado em 2010

Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis

Por Ndubaku, Chudi O., Crawford, Terry D., Chen, Huifen, Boggs, Jason W., Drobnick, Joy, Harris, Seth F., Jesudason, Rajiv, McNamara, Erin, Nonomiya, Jim, Sambrone, Amy, Schmidt, Stephen, Smyczek, Tanya, Vitorino, Philip, Wang, Lan, Wu, Ping, Yeung, Stacey, Chen, Jinhua, Chen, Kevin, Ding, Charles Z., Wang, Tao, Xu, Zijin, Gould, Stephen E., Murray, Lesley J., Ye, Weilan
Publicado no ACS Med Chem Lett (2015)

SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis

Por Jacobs, Robert T., Nare, Bakela, Wring, Stephen A., Orr, Matthew D., Chen, Daitao, Sligar, Jessica M., Jenks, Matthew X., Noe, Robert A., Bowling, Tana S., Mercer, Luke T., Rewerts, Cindy, Gaukel, Eric, Owens, Jennifer, Parham, Robin, Randolph, Ryan, Beaudet, Beth, Bacchi, Cyrus J., Yarlett, Nigel, Plattner, Jacob J., Freund, Yvonne, Ding, Charles, Akama, Tsutomu, Zhang, Y.-K., Brun, Reto, Kaiser, Marcel, Scandale, Ivan, Don, Robert
Publicado em 2011

Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice

Por Purkey, Hans E., Robarge, Kirk, Chen, Jinhua, Chen, Zhongguo, Corson, Laura B., Ding, Charles Z., DiPasquale, Antonio G., Dragovich, Peter S., Eigenbrot, Charles, Evangelista, Marie, Fauber, Benjamin P., Gao, Zhenting, Ge, Hongxiu, Hitz, Anna, Ho, Qunh, Labadie, Sharada S., Lai, Kwong Wah, Liu, Wenfeng, Liu, Yajing, Li, Chiho, Ma, Shuguang, Malek, Shiva, O’Brien, Thomas, Pang, Jodie, Peterson, David, Salphati, Laurent, Sideris, Steve, Ultsch, Mark, Wei, BinQing, Yen, Ivana, Yue, Qin, Zhang, Huihui, Zhou, Aihe
Publicado no ACS Med Chem Lett (2016)

Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase

Por Palencia, Andrés, Li, Xianfeng, Bu, Wei, Choi, Wai, Ding, Charles Z., Easom, Eric E., Feng, Lisa, Hernandez, Vincent, Houston, Paul, Liu, Liang, Meewan, Maliwan, Mohan, Manisha, Rock, Fernando L., Sexton, Holly, Zhang, Suoming, Zhou, Yasheen, Wan, Baojie, Wang, Yuehong, Franzblau, Scott G., Woolhiser, Lisa, Gruppo, Veronica, Lenaerts, Anne J., O'Malley, Theresa, Parish, Tanya, Cooper, Christopher B., Waters, M. Gerard, Ma, Zhenkun, Ioerger, Thomas R., Sacchettini, James C., Rullas, Joaquín, Angulo-Barturen, Iñigo, Pérez-Herrán, Esther, Mendoza, Alfonso, Barros, David, Cusack, Stephen, Plattner, Jacob J., Alley, M. R. K.
Publicado no Antimicrob Agents Chemother (2016)

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

Por Zeggini, Eleftheria, Scott, Laura J., Saxena, Richa, Voight, Benjamin F., Marchini, Jonathan L, Hu, Tainle, de Bakker, Paul IW, Abecasis, Gonçalo R, Almgren, Peter, Andersen, Gitte, Ardlie, Kristin, Boström, Kristina Bengtsson, Bergman, Richard N, Bonnycastle, Lori L, Borch-Johnsen, Knut, Burtt, Noël P, Chen, Hong, Chines, Peter S, Daly, Mark J, Deodhar, Parimal, Ding, Charles, Doney, Alex S F, Duren, William L, Elliott, Katherine S, Erdos, Michael R, Frayling, Timothy M, Freathy, Rachel M, Gianniny, Lauren, Grallert, Harald, Grarup, Niels, Groves, Christopher J, Guiducci, Candace, Hansen, Torben, Herder, Christian, Hitman, Graham A, Hughes, Thomas E, Isomaa, Bo, Jackson, Anne U, Jørgensen, Torben, Kong, Augustine, Kubalanza, Kari, Kuruvilla, Finny G, Kuusisto, Johanna, Langenberg, Claudia, Lango, Hana, Lauritzen, Torsten, Li, Yun, Lindgren, Cecilia M, Lyssenko, Valeriya, Marvelle, Amanda F, Meisinger, Christa, Midthjell, Kristian, Mohlke, Karen L, Morken, Mario A, Morris, Andrew D, Narisu, Narisu, Nilsson, Peter, Owen, Katharine R, Palmer, Colin NA, Payne, Felicity, Perry, John RB, Pettersen, Elin, Platou, Carl, Prokopenko, Inga, Qi, Lu, Qin, Li, Rayner, Nigel W, Rees, Matthew, Roix, Jeffrey J, Sandbæk, Anelli, Shields, Beverley, Sjögren, Marketa, Steinthorsdottir, Valgerdur, Stringham, Heather M, Swift, Amy J, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Timpson, Nicholas J, Tuomi, Tiinamaija, Tuomilehto, Jaakko, Walker, Mark, Watanabe, Richard M, Weedon, Michael N, Willer, Cristen J, Illig, Thomas, Hveem, Kristian, Hu, Frank B, Laakso, Markku, Stefansson, Kari, Pedersen, Oluf, Wareham, Nicholas J, Barroso, Inês, Hattersley, Andrew T, Collins, Francis S, Groop, Leif, McCarthy, Mark I, Boehnke, Michael, Altshuler, David
Publicado em 2008