Regulation of hepatic glucose metabolism in health and disease

par Petersen, Max C., Vatner, Daniel F., Shulman, Gerald I.
Publié dans Nat Rev Endocrinol (2017)

3,5 Diiodo-L-Thyronine (T2) Does Not Prevent Hepatic Steatosis or Insulin Resistance in Fat-Fed Sprague Dawley Rats

par Vatner, Daniel F., Snikeris, Jaclyn, Popov, Violeta, Perry, Rachel J., Rahimi, Yasmeen, Samuel, Varman T.
Publié dans PLoS One (2015)

Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-Hydroxysteroid Dehydrogenase type 1 transgenic mice

par Abulizi, Abudukadier, Camporez, João-Paulo, Zhang, Dongyan, Samuel, Varman T., Shulman, Gerald I., Vatner, Daniel F.
Publié dans Metabolism (2018)

Mechanisms by which adiponectin reverses high fat diet-induced insulin resistance in mice

par Li, Xiruo, Zhang, Dongyan, Vatner, Daniel F., Goedeke, Leigh, Hirabara, Sandro M., Zhang, Ye, Perry, Rachel J., Shulman, Gerald I.
Publié dans Proc Natl Acad Sci U S A (2020)

In Vivo Studies on the Mechanism of Methylenecyclopropylacetic acid and Methylenecyclopropylglycine-Induced Hypoglycemia

par Qiu, Yang, Perry, Rachel J., Camporez, João-Paulo G., Zhang, Xian-Man, Kahn, Mario, Cline, Gary W., Shulman, Gerald I., Vatner, Daniel F.
Publié dans Biochem J (2018)

Adipose glucocorticoid action influences whole-body metabolism via modulation of hepatic insulin action

par Abulizi, Abudukadier, Camporez, João-Paulo, Jurczak, Michael J., Høyer, Kasper F., Zhang, Dongyan, Cline, Gary W., Samuel, Varman T., Shulman, Gerald I., Vatner, Daniel F.
Publié dans FASEB J (2019)

Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents

par Vatner, Daniel F., Goedeke, Leigh, Camporez, Joao-Paulo G., Lyu, Kun, Nasiri, Ali R., Zhang, Dongyan, Bhanot, Sanjay, Murray, Susan F., Still, Christopher D., Gerhard, Glenn S., Shulman, Gerald I., Samuel, Varman T.
Publié dans Diabetologia (2018)

Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis

par Aryal, Binod, Singh, Abhishek K., Zhang, Xinbo, Varela, Luis, Rotllan, Noemi, Goedeke, Leigh, Chaube, Balkrishna, Camporez, Joao-Paulo, Vatner, Daniel F., Horvath, Tamas L., Shulman, Gerald I., Suárez, Yajaira, Fernández-Hernando, Carlos
Publié dans JCI Insight (2018)

Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids

par Vatner, Daniel F., Majumdar, Sachin K., Kumashiro, Naoki, Petersen, Max C., Rahimi, Yasmeen, Gattu, Arijeet K., Bears, Mitchell, Camporez, João-Paulo G., Cline, Gary W., Jurczak, Michael J., Samuel, Varman T., Shulman, Gerald I.
Publié dans Proc Natl Acad Sci U S A (2015)

PEPCK1 Antisense Oligonucleotide Prevents Adiposity and Impairs Hepatic Glycogen Synthesis in High-Fat Male Fed Rats

par Beddow, Sara A, Gattu, Arijeet K, Vatner, Daniel F, Paolella, Lauren, Alqarzaee, Abdulelah, Tashkandi, Nedda, Popov, Violeta B, Church, Christopher D, Rodeheffer, Matthew S, Cline, Gary W, Geisler, John G, Bhanot, Sanjay, Samuel, Varman T
Publié dans Endocrinology (2018)

Membrane-bound sn-1,2-diacylglycerols explain the dissociation of hepatic insulin resistance from hepatic steatosis in MTTP knockout mice

par Abulizi, Abudukadier, Vatner, Daniel F., Ye, Zhang, Wang, Yongliang, Camporez, Joao-Paulo, Zhang, Dongyan, Kahn, Mario, Lyu, Kun, Sirwi, Alaa, Cline, Gary W., Hussain, M. Mahmood, Aspichueta, Patricia, Samuel, Varman T., Shulman, Gerald I.
Publié dans J Lipid Res (2020)

Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents

par Goedeke, Leigh, Bates, Jamie, Vatner, Daniel F., Perry, Rachel J., Wang, Ting, Ramirez, Ricardo, Li, Li, Ellis, Matthew W., Zhang, Dongyan, Wong, Kari E., Beysen, Carine, Cline, Gary W., Ray, Adrian S., Shulman, Gerald I.
Publié dans Hepatology (2018)

Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways

par Vatner, Daniel F., Weismann, Dirk, Beddow, Sara A., Kumashiro, Naoki, Erion, Derek M., Liao, Xiao-Hui, Grover, Gary J., Webb, Paul, Phillips, Kevin J., Weiss, Roy E., Bogan, Jonathan S., Baxter, John, Shulman, Gerald I., Samuel, Varman T.
Publié 2013

Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans

par ter Horst, Kasper W., Gilijamse, Pim W., Versteeg, Ruth I., Ackermans, Mariette T., Nederveen, Aart J., la Fleur, Susanne E., Romijn, Johannes A., Nieuwdorp, Max, Zhang, Dongyan, Samuel, Varman T., Vatner, Daniel F., Petersen, Kitt F., Shulman, Gerald I., Serlie, Mireille J.
Publié dans Cell Rep (2017)

Metabolic control analysis of hepatic glycogen synthesis in vivo

par Nozaki, Yuichi, Petersen, Max C., Zhang, Dongyan, Vatner, Daniel F., Perry, Rachel J., Abulizi, Abudukadier, Haedersdal, Sofie, Zhang, Xian-Man, Butrico, Gina M., Samuel, Varman T., Mason, Graeme F., Cline, Gary W., Petersen, Kitt F., Rothman, Douglas L., Shulman, Gerald I.
Publié dans Proc Natl Acad Sci U S A (2020)

Hepatic Insulin Resistance Is Not Pathway Selective in Humans With Nonalcoholic Fatty Liver Disease

par ter Horst, Kasper W., Vatner, Daniel F., Zhang, Dongyan, Cline, Gary W., Ackermans, Mariette T., Nederveen, Aart J., Verheij, Joanne, Demirkiran, Ahmet, van Wagensveld, Bart A., Dallinga-Thie, Geesje M., Nieuwdorp, Max, Romijn, Johannes A., Shulman, Gerald I., Serlie, Mireille J.
Publié dans Diabetes Care (2021)

Metformin Inhibits Gluconeogenesis by a Redox-Dependent Mechanism In Vivo

par Madiraju, Anila K., Qiu, Yang, Perry, Rachel J., Rahimi, Yasmeen, Zhang, Xian-Man, Zhang, Dongyan, Camporez, João-Paulo G., Cline, Gary W., Butrico, Gina M., Kemp, Bruce E., Casals, Gregori, Steinberg, Gregory R., Vatner, Daniel F., Petersen, Kitt Falk, Shulman, Gerald I.
Publié dans Nat Med (2018)

Targeting steroid receptor coactivator 1 with antisense oligonucleotides increases insulin-stimulated skeletal muscle glucose uptake in chow-fed and high-fat-fed male rats

par Cantley, Jennifer L., Vatner, Daniel F., Galbo, Thomas, Madiraju, Anila, Petersen, Max, Perry, Rachel J., Kumashiro, Naoki, Guebre-Egziabher, Fitsum, Gattu, Arijeet K., Stacy, Mitchel R., Dione, Donald P., Sinusas, Albert J., Ragolia, Louis, Hall, Christopher E., Manchem, Vara Prasad, Bhanot, Sanjay, Bogan, Jonathan S., Samuel, Varman T.
Publié 2014

Role of Patatin-Like Phospholipase Domain-Containing 3 on Lipid-Induced Hepatic Steatosis and Insulin Resistance in Rats

par Kumashiro, Naoki, Yoshimura, Toru, Cantley, Jennifer L, Majumdar, Sachin K, Guebre-Egziabher, Fitsum, Kursawe, Romy, Vatner, Daniel F, Fat, Ioana, Kahn, Mario, Erion, Derek M, Zhang, Xian-Man, Zhang, Dongyan, Manchem, Vara Prasad, Bhanot, Sanjay, Gerhard, Glenn S, Petersen, Kitt F, Cline, Gary W, Samuel, Varman T, Shulman, Gerald I
Publié 2013

Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance

par Schumann, Tina, König, Jörg, von Loeffelholz, Christian, Vatner, Daniel F., Zhang, Dongyan, Perry, Rachel J., Bernier, Michel, Chami, Jason, Henke, Christine, Kurzbach, Anica, El-Agroudy, Nermeen N., Willmes, Diana M., Pesta, Dominik, de Cabo, Rafael, O´Sullivan, John F., Simon, Eric, Shulman, Gerald I., Hamilton, Bradford S., Birkenfeld, Andreas L.
Publié dans Commun Biol (2021)