Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents

AIMS/HYPOTHESIS: Targeting regulators of adipose tissue lipoprotein lipase could enhance adipose lipid clearance, prevent ectopic lipid accumulation and consequently ameliorate insulin resistance and type 2 diabetes. Angiopoietin-like 8 (ANGPTL8) is an insulin-regulated lipoprotein lipase inhibitor...

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Detalhes bibliográficos
Publicado no:Diabetologia
Main Authors: Vatner, Daniel F., Goedeke, Leigh, Camporez, Joao-Paulo G., Lyu, Kun, Nasiri, Ali R., Zhang, Dongyan, Bhanot, Sanjay, Murray, Susan F., Still, Christopher D., Gerhard, Glenn S., Shulman, Gerald I., Samuel, Varman T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940564/
https://ncbi.nlm.nih.gov/pubmed/29497783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-018-4579-1
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