Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids

A central paradox in type 2 diabetes is the apparent selective nature of hepatic insulin resistance—wherein insulin fails to suppress hepatic glucose production yet continues to stimulate lipogenesis, resulting in hyperglycemia, hyperlipidemia, and hepatic steatosis. Although efforts to explain this...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Vatner, Daniel F., Majumdar, Sachin K., Kumashiro, Naoki, Petersen, Max C., Rahimi, Yasmeen, Gattu, Arijeet K., Bears, Mitchell, Camporez, João-Paulo G., Cline, Gary W., Jurczak, Michael J., Samuel, Varman T., Shulman, Gerald I.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4313795/
https://ncbi.nlm.nih.gov/pubmed/25564660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423952112
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