Metformin Inhibits Gluconeogenesis by a Redox-Dependent Mechanism In Vivo

Metformin, the universal first-line treatment for type 2 diabetes, exerts its therapeutic glucose-lowering effects by inhibiting hepatic gluconeogenesis. However, the primary molecular mechanism of this biguanide remains unresolved, though it has been suggested to act, at least partially, by mitocho...

Full description

Saved in:
Bibliographic Details
Published in:Nat Med
Main Authors: Madiraju, Anila K., Qiu, Yang, Perry, Rachel J., Rahimi, Yasmeen, Zhang, Xian-Man, Zhang, Dongyan, Camporez, João-Paulo G., Cline, Gary W., Butrico, Gina M., Kemp, Bruce E., Casals, Gregori, Steinberg, Gregory R., Vatner, Daniel F., Petersen, Kitt Falk, Shulman, Gerald I.
Format: Artigo
Language:Inglês
Published: 2018
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6129196/
https://ncbi.nlm.nih.gov/pubmed/30038219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0125-4
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items