Glucagon stimulates gluconeogenesis by InsP(3)R-I mediated hepatic lipolysis

While it is well-established that alterations in the portal vein insulin/glucagon ratio play a major role in causing dysregulated hepatic glucose metabolism in type 2 diabetes (T2D)(1–3), the mechanisms by which glucagon alters hepatic glucose production and mitochondrial oxidation remain poorly und...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nature
Auteurs principaux: Perry, Rachel J., Zhang, Dongyan, Guerra, Mateus T., Brill, Allison L., Goedeke, Leigh, Nasiri, Ali R., Rabin-Court, Aviva, Wang, Yongliang, Peng, Liang, Dufour, Sylvie, Zhang, Ye, Zhang, Xian-Man, Butrico, Gina M., Toussaint, Keshia, Nozaki, Yuichi, Cline, Gary W., Petersen, Kitt Falk, Nathanson, Michael H., Ehrlich, Barbara E., Shulman, Gerald I.
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7101062/
https://ncbi.nlm.nih.gov/pubmed/32132708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2074-6
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