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InsP3 Receptor Regulates Hepatic Gluconeogenesis in Fasting and Diabetes
In the fasted state, increases in circulating glucagon promote hepatic glucose production through induction of the gluconeogenic program. Triggering of the cAMP pathway increases gluconeogenic gene expression via the de-phosphorylation of the CREB coactivator CRTC2 (1). Glucagon promotes CRTC2 depho...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3343222/ https://ncbi.nlm.nih.gov/pubmed/22495310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10988 |
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