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The CREB Coactivator CRTC2 Links Hepatic ER Stress and Fasting Gluconeogenesis

In fasted mammals, circulating pancreatic glucagon stimulates hepatic gluconeogenesis in part through the CREB Regulated Transcription Coactivator 2 (CRTC2; also referred to as TORC2) 1,2. Hepatic glucose production is elevated in obesity, reflecting chronic increases in endoplasmic reticulum (ER) s...

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Autors principals: Wang, Yiguo, Vera, Liliana, Fischer, Wolfgang H., Montminy, Marc
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730924/
https://ncbi.nlm.nih.gov/pubmed/19543265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08111
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