Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity

Under fasting conditions, increases in circulating concentrations of pancreatic glucagon maintain glucose homeostasis through induction of gluconeogenic genes by the CREB coactivator CRTC2. Hepatic CRTC2 activity is elevated in obesity, although the extent to which this cofactor contributes to atten...

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Bibliographic Details
Main Authors: Wang, Yiguo, Inoue, Hiroshi, Ravnskjaer, Kim, Viste, Kristin, Miller, Nina, Liu, Yi, Hedrick, Susan, Vera, Liliana, Montminy, Marc
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2010
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840317/
https://ncbi.nlm.nih.gov/pubmed/20133702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914897107
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