Hepatic Insulin Resistance Following Chronic Activation of the CREB Coactivator CRTC2

Under fasting conditions, increases in circulating concentrations of glucagon maintain glucose homeostasis via the induction of hepatic gluconeogenesis. Triggering of the cAMP pathway in hepatocytes stimulates the gluconeogenic program via the PKA-mediated phosphorylation of CREB and dephosphorylati...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Hogan, Meghan F., Ravnskjaer, Kim, Matsumura, Shigenobu, Huising, Mark O., Hull, Rebecca L., Kahn, Steven E., Montminy, Marc
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Metabolism
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646253/
https://ncbi.nlm.nih.gov/pubmed/26342077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.679266
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