Hepatic Insulin Resistance Following Chronic Activation of the CREB Coactivator CRTC2

Under fasting conditions, increases in circulating concentrations of glucagon maintain glucose homeostasis via the induction of hepatic gluconeogenesis. Triggering of the cAMP pathway in hepatocytes stimulates the gluconeogenic program via the PKA-mediated phosphorylation of CREB and dephosphorylati...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Hogan, Meghan F., Ravnskjaer, Kim, Matsumura, Shigenobu, Huising, Mark O., Hull, Rebecca L., Kahn, Steven E., Montminy, Marc
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646253/
https://ncbi.nlm.nih.gov/pubmed/26342077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.679266
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