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Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity
Under fasting conditions, increases in circulating concentrations of pancreatic glucagon maintain glucose homeostasis through induction of gluconeogenic genes by the CREB coactivator CRTC2. Hepatic CRTC2 activity is elevated in obesity, although the extent to which this cofactor contributes to atten...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2840317/ https://ncbi.nlm.nih.gov/pubmed/20133702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914897107 |
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