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InsP3R-Ca(2+) signaling takes center stage in the hormonal regulation of hepatic gluconeogenesis
During fasting, dephosphorylation-dependent activation of the CREB coactivator CRTC2 by glucagon is crucial for activation of the hepatic gluconeogenic program, but the molecular mechanism by which hormones regulate CRTC2 activation remains unclear. A recent report in Nature showed that PKA-dependen...
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| Natura: | Artigo |
| Lingua: | Inglês |
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Nature Publishing Group
2012
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3494392/ https://ncbi.nlm.nih.gov/pubmed/22710799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2012.95 |
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