InsP3R-Ca(2+) signaling takes center stage in the hormonal regulation of hepatic gluconeogenesis

Por Matsumoto, Michihiro
Publicado em 2012

Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism

Por Matsumoto, Michihiro, Han, Seongah, Kitamura, Tadahiro, Accili, Domenico
Publicado em 2006

Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver

Por Miyake, Kazuaki, Ogawa, Wataru, Matsumoto, Michihiro, Nakamura, Takehiro, Sakaue, Hiroshi, Kasuga, Masato
Publicado em 2002

A Mutant Allele Encoding DNA Binding–Deficient FoxO1 Differentially Regulates Hepatic Glucose and Lipid Metabolism

Por Cook, Joshua R., Matsumoto, Michihiro, Banks, Alexander S., Kitamura, Tadahiro, Tsuchiya, Kyoichiro, Accili, Domenico
Publicado no Diabetes (2015)

SirT1 gain-of-function increases energy efficiency and prevents diabetes in mice

Por Banks, Alexander S., Kon, Ning, Knight, Colette, Matsumoto, Michihiro, Gutiérrez-Juárez, Roger, Rossetti, Luciano, Gu, Wei, Accili, Domenico
Publicado em 2008

Hepatic insulin signaling regulates VLDL secretion and atherogenesis in mice

Por Han, Seongah, Liang, Chien-Ping, Westerterp, Marit, Senokuchi, Takafumi, Welch, Carrie L., Wang, Qizhi, Matsumoto, Michihiro, Accili, Domenico, Tall, Alan R.
Publicado em 2009

Requirement for Activation of the Serine-Threonine Kinase Akt (Protein Kinase B) in Insulin Stimulation of Protein Synthesis but Not of Glucose Transport

Por Kitamura, Tadahiro, Ogawa, Wataru, Sakaue, Hiroshi, Hino, Yasuhisa, Kuroda, Shoji, Takata, Masafumi, Matsumoto, Michihiro, Maeda, Tetsuo, Konishi, Hiroaki, Kikkawa, Ushio, Kasuga, Masato
Publicado em 1998

Requirement of Atypical Protein Kinase Cλ for Insulin Stimulation of Glucose Uptake but Not for Akt Activation in 3T3-L1 Adipocytes

Por Kotani, Ko, Ogawa, Wataru, Matsumoto, Michihiro, Kitamura, Tadahiro, Sakaue, Hiroshi, Hino, Yasuhisa, Miyake, Kazuaki, Sano, Wataru, Akimoto, Kazunori, Ohno, Shigeo, Kasuga, Masato
Publicado em 1998

Foxo1 Links Hyperglycemia to LDL Oxidation and Endothelial Nitric Oxide Synthase Dysfunction in Vascular Endothelial Cells

Por Tanaka, Jun, Qiang, Li, Banks, Alexander S., Welch, Carrie L., Matsumoto, Michihiro, Kitamura, Tadahiro, Ido-Kitamura, Yukari, DePinho, Ronald A., Accili, Domenico
Publicado em 2009

The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch

Por Sakai, Mashito, Tujimura-Hayakawa, Tomoko, Yagi, Takashi, Yano, Hiroyuki, Mitsushima, Masaru, Unoki-Kubota, Hiroyuki, Kaburagi, Yasushi, Inoue, Hiroshi, Kido, Yoshiaki, Kasuga, Masato, Matsumoto, Michihiro
Publicado no Nat Commun (2016)

Forkhead Transcription Factors (FoxOs) Promote Apoptosis of Insulin-Resistant Macrophages During Cholesterol-Induced Endoplasmic Reticulum Stress

Por Senokuchi, Takafumi, Liang, Chien-Ping, Seimon, Tracie A., Han, Seongah, Matsumoto, Michihiro, Banks, Alexander S., Paik, Ji-Hye, DePinho, Ronald A., Accili, Domenico, Tabas, Ira, Tall, Alan R.
Publicado em 2008

Endoplasmic Reticulum Stress Inhibits STAT3-Dependent Suppression of Hepatic Gluconeogenesis via Dephosphorylation and Deacetylation

Por Kimura, Kumi, Yamada, Tomoko, Matsumoto, Michihiro, Kido, Yoshiaki, Hosooka, Tetsuya, Asahara, Shun-ichiro, Matsuda, Tomokazu, Ota, Tsuguhito, Watanabe, Hiroshi, Sai, Yoshimichi, Miyamoto, Kenichi, Kaneko, Shuichi, Kasuga, Masato, Inoue, Hiroshi
Publicado em 2012

PKCλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity

Por Matsumoto, Michihiro, Ogawa, Wataru, Akimoto, Kazunori, Inoue, Hiroshi, Miyake, Kazuaki, Furukawa, Kensuke, Hayashi, Yoshitake, Iguchi, Haruhisa, Matsuki, Yasushi, Hiramatsu, Ryuji, Shimano, Hitoshi, Yamada, Nobuhiro, Ohno, Shigeo, Kasuga, Masato, Noda, Tetsuo
Publicado em 2003

PKCλ regulates glucose-induced insulin secretion through modulation of gene expression in pancreatic β cells

Por Hashimoto, Naoko, Kido, Yoshiaki, Uchida, Tohru, Matsuda, Tomokazu, Suzuki, Kazuhisa, Inoue, Hiroshi, Matsumoto, Michihiro, Ogawa, Wataru, Maeda, Sakan, Fujihara, Hiroaki, Ueta, Yoichi, Uchiyama, Yasuo, Akimoto, Kazunori, Ohno, Shigeo, Noda, Tetsuo, Kasuga, Masato
Publicado em 2005

The Obesity Susceptibility Gene Carboxypeptidase E Links FoxO1 Signaling in Hypothalamic Pro–opiomelanocortin Neurons with Regulation of Food Intake

Por Plum, Leona, Lin, Hua V., Dutia, Roxanne, Tanaka, Jun, Aizawa, Kumiko S., Matsumoto, Michihiro, Kim, Andrea J., Cawley, Niamh X., Paik, Ji–Hye, Loh, Y. Peng, DePinho, Ronald A., Wardlaw, Sharon L., Accili, Domenico
Publicado em 2009

Overexpression of KLF15 Transcription Factor in Adipocytes of Mice Results in Down-regulation of SCD1 Protein Expression in Adipocytes and Consequent Enhancement of Glucose-induced...

Por Nagare, Tomoki, Sakaue, Hiroshi, Matsumoto, Michihiro, Cao, Yongheng, Inagaki, Kenjiro, Sakai, Mashito, Takashima, Yasuhiro, Nakamura, Kyoko, Mori, Toshiyuki, Okada, Yuko, Matsuki, Yasushi, Watanabe, Eijiro, Ikeda, Kazutaka, Taguchi, Ryo, Kamimura, Naomi, Ohta, Shigeo, Hiramatsu, Ryuji, Kasuga, Masato
Publicado em 2011

Ablation of TSC2 Enhances Insulin Secretion by Increasing the Number of Mitochondria through Activation of mTORC1

Por Koyanagi, Maki, Asahara, Shun-ichiro, Matsuda, Tomokazu, Hashimoto, Naoko, Shigeyama, Yutaka, Shibutani, Yuki, Kanno, Ayumi, Fuchita, Megumi, Mikami, Tomoko, Hosooka, Tetsutya, Inoue, Hiroshi, Matsumoto, Michihiro, Koike, Masato, Uchiyama, Yasuo, Noda, Tetsuo, Seino, Susumu, Kasuga, Masato, Kido, Yoshiaki
Publicado em 2011

Histidine Augments the Suppression of Hepatic Glucose Production by Central Insulin Action

Por Kimura, Kumi, Nakamura, Yusuke, Inaba, Yuka, Matsumoto, Michihiro, Kido, Yoshiaki, Asahara, Shun-ichiro, Matsuda, Tomokazu, Watanabe, Hiroshi, Maeda, Akifumi, Inagaki, Fuyuhiko, Mukai, Chisato, Takeda, Kiyoshi, Akira, Shizuo, Ota, Tsuguhito, Nakabayashi, Hajime, Kaneko, Shuichi, Kasuga, Masato, Inoue, Hiroshi
Publicado em 2013

Ablation of C/EBPβ alleviates ER stress and pancreatic β cell failure through the GRP78 chaperone in mice

Por Matsuda, Tomokazu, Kido, Yoshiaki, Asahara, Shun-ichiro, Kaisho, Tsuneyasu, Tanaka, Takashi, Hashimoto, Naoko, Shigeyama, Yutaka, Takeda, Akihiko, Inoue, Tae, Shibutani, Yuki, Koyanagi, Maki, Hosooka, Tetsuya, Matsumoto, Michihiro, Inoue, Hiroshi, Uchida, Tohru, Koike, Masato, Uchiyama, Yasuo, Akira, Shizuo, Kasuga, Masato
Publicado em 2009

Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c

Por Asahara, Shun-ichiro, Etoh, Hiroaki, Inoue, Hiroyuki, Teruyama, Kyoko, Shibutani, Yuki, Ihara, Yuka, Kawada, Yukina, Bartolome, Alberto, Hashimoto, Naoko, Matsuda, Tomokazu, Koyanagi-Kimura, Maki, Kanno, Ayumi, Hirota, Yushi, Hosooka, Tetsuya, Nagashima, Kazuaki, Nishimura, Wataru, Inoue, Hiroshi, Matsumoto, Michihiro, Higgins, Michael J., Yasuda, Kazuki, Inagaki, Nobuya, Seino, Susumu, Kasuga, Masato, Kido, Yoshiaki
Publicado no Proc Natl Acad Sci U S A (2015)