The Obesity Susceptibility Gene Carboxypeptidase E Links FoxO1 Signaling in Hypothalamic Pro–opiomelanocortin Neurons with Regulation of Food Intake

Reduced food intake brings about an adaptive decrease in energy expenditure that contributes to the recidivism of obesity following weight loss. Insulin and leptin inhibit food intake through actions in the central nervous system that are partly mediated by FoxO1. We show that FoxO1 ablation in pro–...

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Main Authors: Plum, Leona, Lin, Hua V., Dutia, Roxanne, Tanaka, Jun, Aizawa, Kumiko S., Matsumoto, Michihiro, Kim, Andrea J., Cawley, Niamh X., Paik, Ji–Hye, Loh, Y. Peng, DePinho, Ronald A., Wardlaw, Sharon L., Accili, Domenico
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2777744/
https://ncbi.nlm.nih.gov/pubmed/19767734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2026
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