Ablation of C/EBPβ alleviates ER stress and pancreatic β cell failure through the GRP78 chaperone in mice

Pancreatic β cell failure is thought to underlie the progression from glucose intolerance to overt diabetes, and ER stress is implicated in such β cell dysfunction. We have now shown that the transcription factor CCAAT/enhancer-binding protein β (C/EBPβ) accumulated in the islets of diabetic animal...

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Main Authors: Matsuda, Tomokazu, Kido, Yoshiaki, Asahara, Shun-ichiro, Kaisho, Tsuneyasu, Tanaka, Takashi, Hashimoto, Naoko, Shigeyama, Yutaka, Takeda, Akihiko, Inoue, Tae, Shibutani, Yuki, Koyanagi, Maki, Hosooka, Tetsuya, Matsumoto, Michihiro, Inoue, Hiroshi, Uchida, Tohru, Koike, Masato, Uchiyama, Yasuo, Akira, Shizuo, Kasuga, Masato
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2009
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798684/
https://ncbi.nlm.nih.gov/pubmed/19955657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39721
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