Biphasic Response of Pancreatic β-Cell Mass to Ablation of Tuberous Sclerosis Complex 2 in Mice

Recent studies have demonstrated the importance of insulin or insulin-like growth factor 1 (IGF-1) for regulation of pancreatic β-cell mass. Given the role of tuberous sclerosis complex 2 (TSC2) as an upstream molecule of mTOR (mammalian target of rapamycin), we examined the effect of TSC2 deficienc...

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Main Authors: Shigeyama, Yutaka, Kobayashi, Toshiyuki, Kido, Yoshiaki, Hashimoto, Naoko, Asahara, Shun-ichiro, Matsuda, Tomokazu, Takeda, Akihiko, Inoue, Tae, Shibutani, Yuki, Koyanagi, Maki, Uchida, Tohru, Inoue, Maki, Hino, Okio, Kasuga, Masato, Noda, Tetsuo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2293082/
https://ncbi.nlm.nih.gov/pubmed/18316403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01695-07
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