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Mourning Dr. Alfred G. Knudson: the two‐hit hypothesis, tumor suppressor genes, and the tuberous sclerosis complex

On July 10, 2016, Alfred G. Knudson, Jr., MD, PhD, a leader in cancer research, died at the age of 93 years. We deeply mourn his loss. Knudson's two‐hit hypothesis, published in 1971, has been fundamental for understanding tumor suppressor genes and familial tumor‐predisposing syndromes. To und...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Hino, Okio, Kobayashi, Toshiyuki
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5276834/
https://ncbi.nlm.nih.gov/pubmed/27862655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13116
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