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Sun exposure causes somatic second-hit mutations and angiofibroma development in tuberous sclerosis complex
Tuberous sclerosis complex (TSC) is characterized by the formation of tumors in multiple organs and is caused by germline mutation in one of two tumor suppressor genes, TSC1 and TSC2. As for other tumor suppressor gene syndromes, the mechanism of somatic second-hit events in TSC tumors is unknown. W...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3959815/ https://ncbi.nlm.nih.gov/pubmed/24271014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt597 |
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