Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex

Mutations in the Tsc1 or Tsc2 genes cause tuberous sclerosis complex (TSC). Tsc1 and Tsc2 proteins form a complex that inhibits mammalian target of rapamycin complex 1 (mTORC1) signalling through Rheb-GTPase. We found that Tsc2(+/−) neurons showed impaired spine synapse formation, which was resistan...

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Библиографические подробности
Главные авторы: Yasuda, Shin, Sugiura, Hiroko, Katsurabayashi, Shutaro, Shimada, Tadayuki, Tanaka, Hidekazu, Takasaki, Kotaro, Iwasaki, Katsunori, Kobayashi, Toshiyuki, Hino, Okio, Yamagata, Kanato
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042127/
https://ncbi.nlm.nih.gov/pubmed/24889507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05155
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