Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex

Mutations in the Tsc1 or Tsc2 genes cause tuberous sclerosis complex (TSC). Tsc1 and Tsc2 proteins form a complex that inhibits mammalian target of rapamycin complex 1 (mTORC1) signalling through Rheb-GTPase. We found that Tsc2(+/−) neurons showed impaired spine synapse formation, which was resistan...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Yasuda, Shin, Sugiura, Hiroko, Katsurabayashi, Shutaro, Shimada, Tadayuki, Tanaka, Hidekazu, Takasaki, Kotaro, Iwasaki, Katsunori, Kobayashi, Toshiyuki, Hino, Okio, Yamagata, Kanato
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4042127/
https://ncbi.nlm.nih.gov/pubmed/24889507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05155
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados