Ablation of TSC2 Enhances Insulin Secretion by Increasing the Number of Mitochondria through Activation of mTORC1

AIM: We previously found that chronic tuberous sclerosis protein 2 (TSC2) deletion induces activation of mammalian target of rapamycin Complex 1 (mTORC1) and leads to hypertrophy of pancreatic beta cells from pancreatic beta cell-specific TSC2 knockout (βTSC2(−/−)) mice. The present study examines t...

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Detalhes bibliográficos
Main Authors: Koyanagi, Maki, Asahara, Shun-ichiro, Matsuda, Tomokazu, Hashimoto, Naoko, Shigeyama, Yutaka, Shibutani, Yuki, Kanno, Ayumi, Fuchita, Megumi, Mikami, Tomoko, Hosooka, Tetsutya, Inoue, Hiroshi, Matsumoto, Michihiro, Koike, Masato, Uchiyama, Yasuo, Noda, Tetsuo, Seino, Susumu, Kasuga, Masato, Kido, Yoshiaki
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158755/
https://ncbi.nlm.nih.gov/pubmed/21886784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023238
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