Redox Regulates Mammalian Target of Rapamycin Complex 1 (mTORC1) Activity by Modulating the TSC1/TSC2-Rheb GTPase Pathway

Mammalian target of rapamycin (mTOR) is a kinase that plays a key role in a wide array of cellular processes and exists in two distinct functional complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). Although mTORC2 is primarily activated by growth factors, mTORC1 is regulated by numerous...

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Bibliographic Details
Main Authors: Yoshida, Sei, Hong, Sungki, Suzuki, Tsukasa, Nada, Shigeyuki, Mannan, Aristotle M., Wang, Junying, Okada, Masato, Guan, Kun-Liang, Inoki, Ken
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173157/
https://ncbi.nlm.nih.gov/pubmed/21784859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.238014
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