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TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity

Target of rapamycin (TOR) plays a central role in cell growth regulation by integrating signals from growth factors, nutrients, and cellular energy levels. TOR forms two distinct physical and functional complexes, termed TOR complex 1 (TORC1) and TOR complex 2 (TORC2). TORC1, which is sensitive to r...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yang, Qian, Inoki, Ken, Kim, Eunjung, Guan, Kun-Liang
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458976/
https://ncbi.nlm.nih.gov/pubmed/16627617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602282103
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