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Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
Target of rapamycin (TOR) is an evolutionally conserved protein kinase in eukaryotes and a central cell growth controller. TOR exists in two distinct complexes, termed TORC1 and TORC2. Mammalian TORC2 has recently been shown to possess kinase activity toward the C-terminal hydrophobic site of Akt/PK...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2006
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1619946/ https://ncbi.nlm.nih.gov/pubmed/17043309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1461206 |
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