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Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy
Perinuclear aggresome formation is a key mechanism to dispose of misfolded proteins that exceed the degradative capacity of ubiquitin–proteasome and autophagy–lysosome systems. Functional blockade of either degradative system leads to an enhanced aggresome formation. The tuberous sclerosis complex–R...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2690031/ https://ncbi.nlm.nih.gov/pubmed/19458266 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903621106 |
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