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The Sin1 PH domain connects mTORC2 to PI3K
The mechanistic target of rapamycin (mTOR) complex 2, mTORC2, is a critical downstream effector of PI3K to stimulate AGC kinase members, including Akt, PKC, and SGK. Liu et al reported that the PH domain of Sin1, an essential component of mTORC2, directly binds the PI3K product PtdIns(3,4,5)P(3) to...
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| Udgivet i: | Cancer Discov |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4638136/ https://ncbi.nlm.nih.gov/pubmed/26526694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-1125 |
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