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Ras, PI3K and mTORC2 – three's a crowd?

The Ras oncogene is notoriously difficult to target with specific therapeutics. Consequently, there is interest to better understand the Ras signaling pathways to identify potential targetable effectors. Recently, the mechanistic target of rapamycin complex 2 (mTORC2) was identified as an evolutiona...

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Pubblicato in:J Cell Sci
Autori principali: Smith, Stephen F., Collins, Shannon E., Charest, Pascale G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists Ltd 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7561475/
https://ncbi.nlm.nih.gov/pubmed/33033115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.234930
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