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Ras, PI3K and mTORC2 – three's a crowd?

The Ras oncogene is notoriously difficult to target with specific therapeutics. Consequently, there is interest to better understand the Ras signaling pathways to identify potential targetable effectors. Recently, the mechanistic target of rapamycin complex 2 (mTORC2) was identified as an evolutiona...

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Bibliografske podrobnosti
izdano v:J Cell Sci
Main Authors: Smith, Stephen F., Collins, Shannon E., Charest, Pascale G.
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists Ltd 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7561475/
https://ncbi.nlm.nih.gov/pubmed/33033115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.234930
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