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Regulation of mTORC1 by PI3K Signaling

The class I phosphoinositide 3-kinase (PI3K) - mechanistic target of rapamycin complex 1 (mTORC1) signaling network directs cellular metabolism and growth. Activation of mTORC1, which is composed of mTOR, Raptor, mLST8, PRAS40, and DEPTOR, depends on the Rag and Rheb GTPases, and requires signals fr...

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Detalhes bibliográficos
Publicado no:Trends Cell Biol
Main Authors: Dibble, Christian C., Cantley, Lewis C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4734635/
https://ncbi.nlm.nih.gov/pubmed/26159692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tcb.2015.06.002
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