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Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP
An enhanced capacity for de novo lipid synthesis is a metabolic feature of most cancer cells that distinguishes them from their cells of origin. However, the mechanisms through which oncogenes alter lipid metabolism are poorly understood. We find that expression of oncogenic PI3K (H1047R) or K-Ras (...
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| Опубликовано в: : | Oncogene |
|---|---|
| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4666838/ https://ncbi.nlm.nih.gov/pubmed/26028026 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.179 |
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