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Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP

An enhanced capacity for de novo lipid synthesis is a metabolic feature of most cancer cells that distinguishes them from their cells of origin. However, the mechanisms through which oncogenes alter lipid metabolism are poorly understood. We find that expression of oncogenic PI3K (H1047R) or K-Ras (...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Oncogene
Egile Nagusiak: Ricoult, Stéphane J. H., Yecies, Jessica L., Ben-Sahra, Issam, Manning, Brendan D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4666838/
https://ncbi.nlm.nih.gov/pubmed/26028026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.179
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