ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

Ataxia-telangiectasia mutated (ATM) is a cellular damage sensor that coordinates the cell cycle with damage-response checkpoints and DNA repair to preserve genomic integrity. However, ATM also has been implicated in metabolic regulation, and ATM deficiency is associated with elevated reactive oxygen...

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Detalhes bibliográficos
Main Authors: Alexander, Angela, Cai, Sheng-Li, Kim, Jinhee, Nanez, Adrian, Sahin, Mustafa, MacLean, Kirsteen H., Inoki, Ken, Guan, Kun-Liang, Shen, Jianjun, Person, Maria D., Kusewitt, Donna, Mills, Gordon B., Kastan, Michael B., Walker, Cheryl Lyn
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840158/
https://ncbi.nlm.nih.gov/pubmed/20160076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913860107
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