ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

Ataxia-telangiectasia mutated (ATM) is a cellular damage sensor that coordinates the cell cycle with damage-response checkpoints and DNA repair to preserve genomic integrity. However, ATM also has been implicated in metabolic regulation, and ATM deficiency is associated with elevated reactive oxygen...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Alexander, Angela, Cai, Sheng-Li, Kim, Jinhee, Nanez, Adrian, Sahin, Mustafa, MacLean, Kirsteen H., Inoki, Ken, Guan, Kun-Liang, Shen, Jianjun, Person, Maria D., Kusewitt, Donna, Mills, Gordon B., Kastan, Michael B., Walker, Cheryl Lyn
التنسيق: Artigo
اللغة:Inglês
منشور في: National Academy of Sciences 2010
الموضوعات:
Biological Sciences
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840158/
https://ncbi.nlm.nih.gov/pubmed/20160076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913860107
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