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Amino acids enhance polyubiquitination of Rheb and its binding to mTORC1 by blocking lysosomal ATXN3 deubiquitinase activity
Amino acid-induced lysosomal mTORC1 localization through the Rag GTPases is a critical step for its activation by Rheb GTPase. However, how the mTORC1 interacts with Rheb on the lysosome remains elusive. We report that amino acids enhance the polyubiquitination of Rheb (Ub-Rheb), which shows a stron...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7665239/ https://ncbi.nlm.nih.gov/pubmed/33157014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.10.004 |
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