Yüklüyor......
Amino acids enhance polyubiquitination of Rheb and its binding to mTORC1 by blocking lysosomal ATXN3 deubiquitinase activity
Amino acid-induced lysosomal mTORC1 localization through the Rag GTPases is a critical step for its activation by Rheb GTPase. However, how the mTORC1 interacts with Rheb on the lysosome remains elusive. We report that amino acids enhance the polyubiquitination of Rheb (Ub-Rheb), which shows a stron...
Kaydedildi:
| Yayımlandı: | Mol Cell |
|---|---|
| Asıl Yazarlar: | , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2020
|
| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7665239/ https://ncbi.nlm.nih.gov/pubmed/33157014 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.10.004 |
| Etiketler: |
Etiketle
Etiket eklenmemiş, İlk siz ekleyin!
|