Amino acids enhance polyubiquitination of Rheb and its binding to mTORC1 by blocking lysosomal ATXN3 deubiquitinase activity

Amino acid-induced lysosomal mTORC1 localization through the Rag GTPases is a critical step for its activation by Rheb GTPase. However, how the mTORC1 interacts with Rheb on the lysosome remains elusive. We report that amino acids enhance the polyubiquitination of Rheb (Ub-Rheb), which shows a stron...

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Bibliographic Details
Published in:Mol Cell
Main Authors: Yao, Yao, Hong, Sungki, Ikeda, Takayuki, Mori, Hiroyuki, MacDougald, Ormond A., Nada, Shigeyuki, Okada, Masato, Inoki, Ken
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7665239/
https://ncbi.nlm.nih.gov/pubmed/33157014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.10.004
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