Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c

Genetic factors are important determinants of the onset and progression of diabetes mellitus. Numerous susceptibility genes for type 2 diabetes, including potassium voltage-gated channel, KQT-like subfamily Q, member1 (KCNQ1), have been identified in humans by genome-wide analyses and other studies....

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Asahara, Shun-ichiro, Etoh, Hiroaki, Inoue, Hiroyuki, Teruyama, Kyoko, Shibutani, Yuki, Ihara, Yuka, Kawada, Yukina, Bartolome, Alberto, Hashimoto, Naoko, Matsuda, Tomokazu, Koyanagi-Kimura, Maki, Kanno, Ayumi, Hirota, Yushi, Hosooka, Tetsuya, Nagashima, Kazuaki, Nishimura, Wataru, Inoue, Hiroshi, Matsumoto, Michihiro, Higgins, Michael J., Yasuda, Kazuki, Inagaki, Nobuya, Seino, Susumu, Kasuga, Masato, Kido, Yoshiaki
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500236/
https://ncbi.nlm.nih.gov/pubmed/26100882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1422104112
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