GCN2 regulates pancreatic β cell mass by sensing intracellular amino acid levels

EIF2AK4, which encodes the amino acid deficiency–sensing protein GCN2, has been implicated as a susceptibility gene for type 2 diabetes in the Japanese population. However, the mechanism by which GCN2 affects glucose homeostasis is unclear. Here, we show that insulin secretion is reduced in individu...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Kanno, Ayumi, Asahara, Shun-ichiro, Furubayashi, Ayuko, Masuda, Katsuhisa, Yoshitomi, Risa, Suzuki, Emi, Takai, Tomoko, Kimura-Koyanagi, Maki, Matsuda, Tomokazu, Bartolome, Alberto, Hirota, Yushi, Yokoi, Norihide, Inaba, Yuka, Inoue, Hiroshi, Matsumoto, Michihiro, Inoue, Kenichi, Abe, Takaya, Wei, Fan-Yan, Tomizawa, Kazuhito, Ogawa, Wataru, Seino, Susumu, Kasuga, Masato, Kido, Yoshiaki
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7253016/
https://ncbi.nlm.nih.gov/pubmed/32376799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.128820
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados