Endoplasmic Reticulum Stress Inhibits STAT3-Dependent Suppression of Hepatic Gluconeogenesis via Dephosphorylation and Deacetylation

In the liver, signal transducer and activator of transcription 3 (STAT3) plays an important role in the suppression of gluconeogenic enzyme expression. While obesity-associated endoplasmic reticulum (ER) stress has been shown to increase hepatic gluconeogenic enzyme expression, the role of ER stress...

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Main Authors: Kimura, Kumi, Yamada, Tomoko, Matsumoto, Michihiro, Kido, Yoshiaki, Hosooka, Tetsuya, Asahara, Shun-ichiro, Matsuda, Tomokazu, Ota, Tsuguhito, Watanabe, Hiroshi, Sai, Yoshimichi, Miyamoto, Kenichi, Kaneko, Shuichi, Kasuga, Masato, Inoue, Hiroshi
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2012
Teme:
Metabolism
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3237645/
https://ncbi.nlm.nih.gov/pubmed/22124464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1684
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