PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes

Glucagon-mediated gene transcription in the liver is critical for maintaining glucose homeostasis. Promoting the induction of gluconeogenic genes and blocking that of insulin receptor substrate (Irs)2 in hepatocytes contributes to the pathogenesis of type 2 diabetes. However, the molecular mechanism...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Sci Rep
Κύριοι συγγραφείς: Yano, Hiroyuki, Sakai, Mashito, Matsukawa, Toshiya, Yagi, Takashi, Naganuma, Takao, Mitsushima, Masaru, Iida, Satoshi, Inaba, Yuka, Inoue, Hiroshi, Unoki-Kubota, Hiroyuki, Kaburagi, Yasushi, Asahara, Shun-ichiro, Kido, Yoshiaki, Minami, Shiro, Kasuga, Masato, Matsumoto, Michihiro
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Nature Publishing Group UK 2018
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155226/
https://ncbi.nlm.nih.gov/pubmed/30250231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-32575-z
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