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Enhanced ROS Generation Mediated by Alzheimer's Disease Presenilin Regulation of InsP(3)R Ca(2+) Signaling
Familial Alzheimer's disease (FAD) is caused by mutations in amyloid precursor protein and presenilins (PS1, PS2). Many FAD-linked PS mutations affect intracellular calcium (Ca(2+)) homeostasis by proximal mechanisms independent of amyloid production by dramatically enhancing gating of the inos...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Mary Ann Liebert, Inc.
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048838/ https://ncbi.nlm.nih.gov/pubmed/20701429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2010.3421 |
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