Učitavanje...
Gain-of-function enhancement of InsP(3) receptor modal gating by familial Alzheimer’s disease-linked presenilin mutants in human cells and mouse neurons
Familial Alzheimer’s disease (FAD) is caused by mutations in amyloid precursor protein or presenilins (PS1, PS2). Many FAD-linked PS mutations affect intracellular calcium (Ca(2+)) homeostasis by mechanisms proximal to and independent of amyloid production, although the molecular details are controv...
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| Glavni autori: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2898196/ https://ncbi.nlm.nih.gov/pubmed/20332427 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000818 |
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