Mechanism of Ca(2+) Disruption in Alzheimer’s Disease by Presenilin Regulation of InsP(3) Receptor Channel Gating

Mutations in presenilins (PS) are the major cause of familial Alzheimer’s disease (FAD) and have been associated with calcium (Ca(2+)) signaling abnormalities. Here, we demonstrate that FAD mutant PS1 (M146L) and PS2 (N141I) interact with the inositol 1,4,5-trisphosphate receptor (InsP(3)R) Ca(2+) r...

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Autori principali: Cheung, King-Ho, Shineman, Diana, Muller, Marioly, Cardenas, Cesar, Mei, Lijuan, Yang, Jun, Tomita, Taisuke, Iwatsubo, Takeshi, Lee, Virginia M.-Y., Foskett, J. Kevin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2495086/
https://ncbi.nlm.nih.gov/pubmed/18579078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2008.04.015
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