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Mechanism of Ca(2+) Disruption in Alzheimer’s Disease by Presenilin Regulation of InsP(3) Receptor Channel Gating
Mutations in presenilins (PS) are the major cause of familial Alzheimer’s disease (FAD) and have been associated with calcium (Ca(2+)) signaling abnormalities. Here, we demonstrate that FAD mutant PS1 (M146L) and PS2 (N141I) interact with the inositol 1,4,5-trisphosphate receptor (InsP(3)R) Ca(2+) r...
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| Autori principali: | , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2008
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2495086/ https://ncbi.nlm.nih.gov/pubmed/18579078 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2008.04.015 |
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