Mechanism of Ca(2+) Disruption in Alzheimer’s Disease by Presenilin Regulation of InsP(3) Receptor Channel Gating

Mutations in presenilins (PS) are the major cause of familial Alzheimer’s disease (FAD) and have been associated with calcium (Ca(2+)) signaling abnormalities. Here, we demonstrate that FAD mutant PS1 (M146L) and PS2 (N141I) interact with the inositol 1,4,5-trisphosphate receptor (InsP(3)R) Ca(2+) r...

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Main Authors: Cheung, King-Ho, Shineman, Diana, Muller, Marioly, Cardenas, Cesar, Mei, Lijuan, Yang, Jun, Tomita, Taisuke, Iwatsubo, Takeshi, Lee, Virginia M.-Y., Foskett, J. Kevin
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2495086/
https://ncbi.nlm.nih.gov/pubmed/18579078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2008.04.015
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