Mechanism of Ca(2+) Disruption in Alzheimer’s Disease by Presenilin Regulation of InsP(3) Receptor Channel Gating

Mutations in presenilins (PS) are the major cause of familial Alzheimer’s disease (FAD) and have been associated with calcium (Ca(2+)) signaling abnormalities. Here, we demonstrate that FAD mutant PS1 (M146L) and PS2 (N141I) interact with the inositol 1,4,5-trisphosphate receptor (InsP(3)R) Ca(2+) r...

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Detalhes bibliográficos
Main Authors: Cheung, King-Ho, Shineman, Diana, Muller, Marioly, Cardenas, Cesar, Mei, Lijuan, Yang, Jun, Tomita, Taisuke, Iwatsubo, Takeshi, Lee, Virginia M.-Y., Foskett, J. Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2495086/
https://ncbi.nlm.nih.gov/pubmed/18579078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2008.04.015
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