Calpain-cleaved Type 1 Inositol 1,4,5-Trisphosphate Receptor (InsP(3)R1) Has InsP(3)-independent Gating and Disrupts Intracellular Ca(2+) Homeostasis

The type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) is a ubiquitous intracellular Ca(2+) release channel that is vital to intracellular Ca(2+) signaling. InsP(3)R1 is a proteolytic target of calpain, which cleaves the channel to form a 95-kDa carboxyl-terminal fragment that includes the tra...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Kopil, Catherine M., Vais, Horia, Cheung, King-Ho, Siebert, Adam P., Mak, Don-On Daniel, Foskett, J. Kevin, Neumar, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195633/
https://ncbi.nlm.nih.gov/pubmed/21859719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.254177
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados