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Calpain-cleaved Type 1 Inositol 1,4,5-Trisphosphate Receptor (InsP(3)R1) Has InsP(3)-independent Gating and Disrupts Intracellular Ca(2+) Homeostasis
The type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) is a ubiquitous intracellular Ca(2+) release channel that is vital to intracellular Ca(2+) signaling. InsP(3)R1 is a proteolytic target of calpain, which cleaves the channel to form a 95-kDa carboxyl-terminal fragment that includes the tra...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3195633/ https://ncbi.nlm.nih.gov/pubmed/21859719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.254177 |
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